We are a UK-wide consortium of doctors and scientists committed to answering urgent questions about COVID-19 quickly, openly, and for the benefit of all. Over the last 9 years we have been preparing for such a major outbreak worldwide International Severe Acute Respiratory Infection Consortium Clinical Characterisation Protocol; our team deployed immediately and has been collecting data and samples since the first cases were reported in the UK.
We have recruited:
The ISARIC4C study has created an open-access integrated analysis platform for linked clincal data from across the NHS for a range of studies, including ISARIC4C, GenOMICC, PHOSP, COG-UK and UK-CIC.
ISARIC4C is funded by two major awards from UK Reasearch and Inovation (UKRI) and The National Institute For Health Research (NIHR). We share data and samples to get answers as fast as possible. We will not end this outbreak sitting on a biobank; our intention is to use every drop of every sample, now, to have the biggest possible impact on the COVID-19 crisis. Any investigators with the ability to contribute can access our data and samples. The ISARIC4C study provides a foundation for other studies, such as clinical trials of new treatments, to help better understand the best way to use interventions.
Lancet 2022 SAGE minutes This analysis provides a clear answer to a simple question: what is the...
ISARIC4C was designed from the outset as a foundation for the UK outbreak response, supporting re...
ISARIC4C and CO-CIN (Tier 0) feed data dynamically to Public Health Scotland, Public Health Engla...
BMJ 9 Mar 2020 Using data from 57, 824 hospital admissions, we developed and validated an easy-t...
BMJ: 2020; 369 Within weeks of being funded, we produced the largest study anywhere in the world...
MedRxiv September 2020; Nature online December 2020 In collaboration with the ISARIC GenOMICC st...
BMJ 2020;370:m3249 We have comprehensively characterised the burden and patterns of disease in c...
The Lancet, 17 July 2021 As well as death, severe COVID-19 disease has effects on many different...
Journal of Virological Methods, April 2022 Accurate and sensitive detection of antibody to SARS-...
Haematologica Early View 8 April 2021 COVID-19 has highlighted the lethal consequences of immuno...
MedRxiv pre-prints 25 March 2021 It is emerging that long-term symptoms are often present in peo...
American Journal of Respiratory Cell and Molecular Biology 26 October 2021 Peripheral blood infl...
MedRxiv pre-prints 21 June 2021 Adults with severe COVID-19 treated with remdesivir were compare...
BMJ Open 30 Sept 2021 Vitamin D deficiency/insufficiency was present in the majority of hospital...
The Lancet: Rheumatology May 07, 2021 Early in the pandemic it was suggested that pre-existing u...
Science Immunology 10 Mar 2021 We have identified new biomarkers of inflammation that both revea...
Nature Immunology (4th September 2020)) This study by Yanchung Peng, Alex Mentzer, Tao Dong an...
Setting the standard ISARIC 4C defined the international reference standard for SARS-CoV-2 serol...
Cell 4 Mar 2021 We showed that the N439K viral mutation has enhanced binding affinity to the ACE...
SSRN July 2020 We have carefully studied the effect of ethnicity on outcomes in hospitalised pat...
Clinical Infectious Diseases 8 Jul 2020 We have explored the mechanisms of viral transmission. O...
The Lancet, 15 August 2020 At the start of the pandemic, ISARIC4C was able to provide convalesce...
American Journal of Respiratory and Critical Care Medicine 2021 ISARIC 4C resources and consorti...
Lancet Respiratory Medicine 4 March 2021 Characterisation of 75 463 hospitalised COVID-19 patien...
Lancet Microbe 2 June 2021 We investigated the frequency and microbiological details of bacteria...
Esmo Open 1 May 2020 The ISARIC4C investigators collaborated with Prof Carlo Palmieri and team...
Eurosurveillance 22 Oct 2020 ISARIC4C provided support to this study looking at population expos...
Viruses 14 Oct 2020 Sequencing the viral genome as the outbreak progresses is important, particu...
EClinical Medicine 22 Feb 2021) Providing data and support to the Trisomy 21 Society, a study wa...
An alternate weekly data share is made with global ISARIC CCP partners in 42 countries and a summ...
Lancet Infectious Diseases 23 Dec 2020 To look at the impact of tiered restrictions, the team fi...
MedRxiv pre-print 4 Dec 2020 Groups of multi-model forecasts can inform the policy response to t...
MedRxiv May 2020 We proposed and established a Diagnostic Evaluation Platform at the University ...
Clinical Infectious Diseases 23 Oct 2020 Providing data and support to the British HIV Associati...
American Journal of Respiratory and Critical Care 15 Dec 2020 We completed an international mult...
Open Forum Infectious Diseases 28 Dec 2020 This study, with support and resources provided by IS...
MedRxiv August 16th 2020. Because of the large scale of the ISARIC-4C study, we were able to d...
European Respiratory Journal 13 Aug 2020 The National COVID-19 Chest Imaging Database (NCCID) is...
Wellcome Open Research 29 Jul 2020 Laboratory diagnosis of SARS-CoV-2 infection uses PCR to dete...
The Remdesivir Statistical Analysis Plan was approved on 16 December 2020.