ISARIC4C (Comprehensive Clinical Characterisation Collaboration)

We are an open, inclusive UK-wide collaboration of doctors and scientists committed to answering urgent questions about emerging infections and public health threats quickly, openly, and for the benefit of all.

Since 2012 we have been preparing for outbreaks worldwide. International Severe Acute Respiratory Infection Consortium Clinical Characterisation Protocol.


ISARIC4C is currently actively recruiting cases in the UK with:

- unexplained acute hepatitis
- monkeypox

Analysis Platform

The ISARIC4C study has created an open-access integrated analysis platform for linked clincal data from across the NHS for a range of studies, including ISARIC4C, GenOMICC, PHOSP, COG-UK and UK-CIC.


ISARIC4C is funded by UK Research and Inovation (UKRI) and The National Institute For Health Research (NIHR). We share data and samples to get answers as fast as possible. Any investigators with the ability to contribute can access our data and samples. The ISARIC4C study provides a foundation for other studies, such as clinical trials of new treatments, to help better understand the best way to use interventions.


Co-Infection with influenza virus is associated with worse outcomes in hospitalised Covid patients

Lancet 2022 SAGE minutes This analysis provides a clear answer to a simple question: what is the...

Whole-genome sequencing reveals host factors underlying critical COVID-19

Nature July 2022 This research article outlines key findings from the GenOMICC study, using whol...

Sharing samples and data

ISARIC4C was designed from the outset as a foundation for the UK outbreak response, supporting re...

Impacting Policy

ISARIC4C and CO-CIN (Tier 0) feed data dynamically to Public Health Scotland, Public Health Engla...

Risk prediction: the 4C Mortality Score

BMJ 9 Mar 2020 Using data from 57, 824 hospital admissions, we developed and validated an easy-t...

Characterisation of hospitalised cases of COVID-19

BMJ: 2020; 369 Within weeks of being funded, we produced the largest study anywhere in the world...

Genetic mechanisms of severe Covid-19

MedRxiv September 2020; Nature online December 2020 In collaboration with the ISARIC GenOMICC st...