ISARIC4C (Coronavirus Clinical Characterisation Consortium)

We are a UK-wide consortium of doctors and scientists committed to answering urgent questions about COVID-19 quickly, openly, and for the benefit of all. Over the last 9 years we have been preparing for such a major outbreak worldwide International Severe Acute Respiratory Infection Consortium Clinical Characterisation Protocol; our team deployed immediately and has been collecting data and samples since the first cases were reported in the UK.

Recruitment

We have recruited:

• 207094 patients at Tier Zero case report forms(CO-CIN)
• 2309 patients at Tier 1/2 (host/viral multiomics)
• 12591 critically-ill patients can also be recruited to a sister study, the ISARIC GenOMICC study

Analysis Platform

The ISARIC4C study has created an open-access integrated analysis platform for linked clincal data from across the NHS for a range of studies, including ISARIC4C, GenOMICC, PHOSP, COG-UK and UK-CIC.

Consortium details

• Project deliverables
• Consortium Authors and Acknowledgements

Funding

ISARIC4C is funded by two major awards from UK Reasearch and Inovation (UKRI) and The National Institute For Health Research (NIHR). A grant from UKRI Medical Research Council with a total value of £5.9M to JK Baillie (PI), University of Edinburgh; MG Semple, University of Liverpool; and P Openshaw, Imperial College London (co-leads). Full list of investigators and specific deliverables. A grant from NIHR with a current value of £8.9M to MG Semple (CI), University of Liverpool; AD Docherty, University of Edinburgh, and CA Green, University of Birmingham. We share data and samples to get answers as fast as possible. We will not end this outbreak sitting on a biobank; our intention is to use every drop of every sample, now, to have the biggest possible impact on the COVID-19 crisis. Any investigators with the ability to contribute can access our data and samples. The ISARIC4C study provides a foundation for other studies, such as clinical trials of new treatments, to help better understand the best way to use interventions.