ISARIC4C (Comprehensive Clinical Characterisation Collaboration)

We are an open, inclusive UK-wide collaboration of doctors and scientists committed to answering urgent questions about emerging infections and public health threats quickly, openly, and for the benefit of all.

Since 2012 we have been preparing for outbreaks worldwide. International Severe Acute Respiratory Infection Consortium Clinical Characterisation Protocol.


ISARIC4C is currently actively recruiting cases in the UK with:

- unexplained acute hepatitis
- monkeypox

Analysis Platform

The ISARIC4C study has created an open-access integrated analysis platform for linked clincal data from across the NHS for a range of studies, including ISARIC4C, GenOMICC, PHOSP, COG-UK and UK-CIC.


ISARIC4C is funded by UK Research and Inovation (UKRI) and The National Institute For Health Research (NIHR). We share data and samples to get answers as fast as possible. Any investigators with the ability to contribute can access our data and samples. The ISARIC4C study provides a foundation for other studies, such as clinical trials of new treatments, to help better understand the best way to use interventions.


Adeno-associated virus 2 infection in children with non-A-E hepatitis

ISARIC4C researchers showed the link between adeno-associated virus 2 (AAV2) and acute hepatitis ...

Genomic investigations of unexplained acute hepatitis in children

ISARIC4C researchers worked closely with researchers led by Prof Judith Breuer at Great Ormond St...

Whole-genome sequencing reveals host factors underlying critical COVID-19

This research article outlines key findings from the GenOMICC study, using whole-genome sequencin...

Co-Infection with influenza virus is associated with worse outcomes in hospitalised Covid patients

SAGE minutes This analysis provides a clear answer to a simple question: what is the effect of c...

Sharing samples and data

ISARIC4C was designed from the outset as a foundation for the UK outbreak response, supporting re...

Impacting Policy

ISARIC4C Tier 0/CO-CIN fed data dynamically through the Outbreak Data Analysis Platform (ODAP) to...

Risk prediction: the 4C Mortality Score

Using data from 57, 824 hospital admissions, we developed and validated an easy-to-use risk strat...

Characterisation of hospitalised cases of COVID-19

Within weeks of being funded, we produced the largest study anywhere in the world of COVID-19 cas...