Sharing samples and data

ISARIC4C was designed from the outset as a foundation for the UK outbreak response, supporting researchers across the country.

The 4C consortium has:

  • Responded to clinical 120 data requests, providing data to 100 collaborators
  • Shipped out a total of 21,000 samples from our hub labs in Liverpool and Glasgow
  • Provided sample sets to 21 different institutions (Universities, Public Health England, NIBSC, Francis Crick Inst., NIH)

Dynamic data feeds from the data analysis platform are provided via API to Public Health in England & Scotland & SPI-M with independent reports prepared by them for NERVTAG and SAGE.

Destination External Samples sent
Array Genotyping / WGS and RNA Seq (Lee Murphy - Edinburgh) 6900
Autoantibody (Ken Smith ) 660
Biochemistry (Chen Hok Toh / Simon Abrams) 230
Biochemistry (Georgios Pollakis - University of Liverpool) 800
Cytokines (Ryan Thwaites - Imperial ) 3000
Diagnostic Evaluation Platform (Alex Mentzer - Oxford) 190
DNA: 16S Microbiome (Debby Bogeart - Edinburgh) 1300
NGS (Emma Thomson / Elen Vink - Glasgow ) 2200
Serology (Public Health England (PHE)) 1800
Proteomics (Calum Semple - University of Liverpool ) 100
Proteomics (CRICK Institute) 700
RNA for viral seq/metagenomics (Julian Hiscox) 600
Request 100 -Steroids and Vit D (Kenneth Ballie, Clark Russel, Natalie Homer - Edinburgh) 320
Pre IDAMAC request (NIBSC - National Institute for Biological Standards and Controls) Y 26
Request 103 - CiC- complement (Claire Harris - Newcastle) Y 860
Request 103 - CiC- complement (Paul Morgan - Cardiff) Y 860
Request 140 -Biomarkers of CNS (Ben Michael - Addenbrookes) Y 64
Request 27 - RNA Seq from throat swabs (Roya Haghighat-Khan - Imperial College London) Y 32
Request 4 - Assay development (Emily Adams - LSTM) Y 130
Request 47 - Metabolomics (Marc Dumas - Imperial - IRDB) Y 780
Request 48 -T-cell responses (Turtle, Klennerman, DeSilva) Y 600
Request 65 - Faecal microbiome (Emily Thornton - University of Oxford) Y 120
Request 96 - Fc-Gamma genotyping (Jim Robinson - University of Leeds) Y 570
Total 23000