ISARIC4C was designed from the outset as a foundation for the UK outbreak response, supporting researchers across the country.
The 4C consortium has:
- Responded to clinical 120 data requests, providing data to 100 collaborators
- Shipped out a total of 21,000 samples from our hub labs in Liverpool and Glasgow
- Provided sample sets to 21 different institutions (Universities, Public Health England, NIBSC, Francis Crick Inst., NIH)
Dynamic data feeds from the data analysis platform are provided via API to Public Health in England & Scotland & SPI-M with independent reports prepared by them for NERVTAG and SAGE.
| Destination | External | Samples sent |
|---|---|---|
| Array Genotyping / WGS and RNA Seq (Lee Murphy - Edinburgh) | 6900 | |
| Autoantibody (Ken Smith ) | 660 | |
| Biochemistry (Chen Hok Toh / Simon Abrams) | 230 | |
| Biochemistry (Georgios Pollakis - University of Liverpool) | 800 | |
| Cytokines (Ryan Thwaites - Imperial ) | 3000 | |
| Diagnostic Evaluation Platform (Alex Mentzer - Oxford) | 190 | |
| DNA: 16S Microbiome (Debby Bogeart - Edinburgh) | 1300 | |
| NGS (Emma Thomson / Elen Vink - Glasgow ) | 2200 | |
| Serology (Public Health England (PHE)) | 1800 | |
| Proteomics (Calum Semple - University of Liverpool ) | 100 | |
| Proteomics (CRICK Institute) | 700 | |
| RNA for viral seq/metagenomics (Julian Hiscox) | 600 | |
| Request 100 -Steroids and Vit D (Kenneth Ballie, Clark Russel, Natalie Homer - Edinburgh) | 320 | |
| Pre IDAMAC request (NIBSC - National Institute for Biological Standards and Controls) | Y | 26 |
| Request 103 - CiC- complement (Claire Harris - Newcastle) | Y | 860 |
| Request 103 - CiC- complement (Paul Morgan - Cardiff) | Y | 860 |
| Request 140 -Biomarkers of CNS (Ben Michael - Addenbrookes) | Y | 64 |
| Request 27 - RNA Seq from throat swabs (Roya Haghighat-Khan - Imperial College London) | Y | 32 |
| Request 4 - Assay development (Emily Adams - LSTM) | Y | 130 |
| Request 47 - Metabolomics (Marc Dumas - Imperial - IRDB) | Y | 780 |
| Request 48 -T-cell responses (Turtle, Klennerman, DeSilva) | Y | 600 |
| Request 65 - Faecal microbiome (Emily Thornton - University of Oxford) | Y | 120 |
| Request 96 - Fc-Gamma genotyping (Jim Robinson - University of Leeds) | Y | 570 |
| Total | 23000 |
