Using data from 57, 824 hospital admissions, we developed and validated an easy-to-use risk stratification score based on commonly available parameters at hospital presentation. The 4C Mortality Score outperformed existing scores, showed utility to directly inform clinical decision making, and can be used to stratify patients admitted to hospital with covid-19 into different management groups. Generation of the 4C mortality score was supported by the Outbreak Data Analysis Platform (ODAP).
The 4C Mortality Score can be found here: isaric4c.net/risk
The 4C Mortality Score has been extensively validated in independent studies across the world. Validation of the 4C score showed similar discrimination in the following countries:
- Singapore
- Japan
- United States
- Brazil
- Brazil and Spain
- Belgium
- Saudi Arabia
- Australia
- France
- The Netherlands
- Italy
- Pakistan
- Turkey
- Canada, Toronto
- Canada, Ontario
- Romania
Using data from the second wave of the COVID-19 pandemic in the UK, a prospective validation study showed that both the 4C Mortality Score and 4C Deterioration Score demonstrated consistent performance to predict clinical deterioration and mortality. Despite recent advances in the treatment and management of adults hospitalised with COVID-19, both scores can continue to inform clinical decision making.
