This page is intended to provide updates for participants on the work that has been done with their samples and data. We will keep this page updated with research results, reports and plans.
During its first 3 months, the ISARIC 4C consortium expanded from the initial 34 co-investigators to more than 150 active contributors, and provides a data and sampling infrastructure for follow-up of COVID cases in the P-HOSP consortium.
Supporting autopsy work ISARIC 4C resources and consortium partners supported the COVID-19 post-mortem case series reported here: https://www.medrxiv.org/content/10.1101/2020.07.02.20145003v1. This is one of several pieces of evidence that changes the model of COVID pathogenesis, supporting a primary role for the host immune system in causing fatal disease.
Understanding the impact of ethnicity We have carefully studied the effect of ethnicity on outcomes in hospitalised patients, revealing the effect of comorbidities in mediating part of the increased susceptibility in some ethic groups. The pre-print is here: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3618215
Predicting risk We have produced the largest study anywhere in the world of COVID-19 cases (25,000 cases so far), enabling us to produce the most accurate risk prediction models for the UK population. These will continue to improve. The first one shows that obesity is an important risk factor amongst many. This finding will help to protect people at high risk of death from COVID-19. Our preprint is now online Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol See the final peer-reviewed paper here. We have also produced an interactive infographic to help communicate these findings.
Testing the tests We proposed and established a Diagnostic Evaluation Platform at the University of Oxford (led by Dr Alex Mentzer) which is already being used to provide evidence to the UK government about the performance of new diagnostic and antibody tests. This work is essential because if tests work well they can save lives; if they don’t, they can cause enormous damage. See the paper here.
Defining the international reference standard for SARS-CoV-2 serology ISARIC 4C provided the first samples to the National Institute for Biological Standards and Control (NIBSC) from COVID-19 cases. These were used to make the WHO International Standard for SARS-CoV-2 serology, which will be used all over the world to compare results from blood tests for COVID-19. 7 of the 11 patients who contributed to the standard were recruited by ISARIC 4C.